[Pre-print] A novel thermally assisted membrane introduction mass spectrometry (MIMS) interface for the rapid and sensitive on-line measurement of volatile and semi-volatile organic contaminants in air and water at parts-per trillion level

Abstract

A coaxially heated membrane introduction mass spectrometry (MIMS) sampling interface is presented that demonstrates improved on-line performance for the direct measurement of semi-volatile organic compounds (SVOCs) in air and water samples at parts-per-trillion levels. The device is based on a polydimethylsiloxane (PDMS) capillary hollow fibre membrane (HFM) in a pneumatically assisted ‘flow-over’ configuration that is resistively heated on the membrane interior via a coaxial nichrome wire, establishing a thermal gradient counter to the analyte concentration gradient. This arrangement allows for continuous and/or pulsed heating modes, affording excellent sensitivity for the on-line measurement of SVOCs while retaining sensitivity for volatile organic compounds (VOCs). In addition, the signal response time for SVOCs is reduced substantially over conventional ‘flow-over’ MIMS interfaces. Separation and quantitation of analytes are achieved using quadrupole ion trap tandem mass spectrometry.