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dc.contributor.authorBorden, Scott A.
dc.contributor.authorSaatchi, Armin
dc.contributor.authorVandergrift, Gregory W.
dc.contributor.authorPalaty, Jan
dc.contributor.authorLysyshyn, Mark
dc.contributor.authorGill, Chris G.
dc.date.accessioned2021-09-15T20:51:32Z
dc.date.available2021-09-15T20:51:32Z
dc.date.issued2021-08-04
dc.identifier.citationBorden, S.A., Saatchi, A., Vandergrift, G.W., Palaty, J., Lysyshyn, M., & Gill, C.G. (2021). A new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry. Drug and Alcohol Review, 1-8. https://doi.org/10.1111/dar.13370en_US
dc.identifier.issn1465-3362
dc.identifier.otherDOI: 10.1111/dar.13370
dc.identifier.urihttps://viurrspace.ca/handle/10613/24515
dc.identifier.urihttp://dx.doi.org/10.25316/IR-16337
dc.description.abstractIntroduction. Drug checking services for harm reduction and overdose prevention have been implemented in many jurisdictions as a public health intervention in response to the opioid overdose crisis. This study demonstrates the first on-site use of paper spray mass spectrometry for quantitative drug checking to address the limitations of current on-site drug testing technologies. Methods. Paper spray mass spectrometry was used to provide on-site drug checking services at a supervised consumption site in the Downtown Eastside of Vancouver, British Columbia, Canada during a 2-day pilot test in August 2019. The method included the targeted quantitative measurement of 49 drugs and an untargeted full scan to assist in identifying unknown/unexpected components. Results. During the pilot, 113 samples were submitted for analysis, with 88 (78%) containing the client expected substance. Fentanyl was detected in 45 of 59 expected fentanyl samples, and in 50 (44%) samples overall at a median concentration of 3.6% (w/w%). The synthetic precursor of fentanyl, 4-anilino-N-phenethyl-piperidine (4-ANPP), was found in 74.0% of all fentanyl samples at a median concentration of 2.2%, suggesting widespread poor manufacturing practices. Etizolam was detected in 10 submitted samples anticipated to be fentanyl at a median concentration of 2.5%. No clients submitting these samples expected etizolam or a benzodiazepine in their sample. In three instances, it was co-measured with fentanyl, and in seven cases it was detected alone. Discussion and Conclusions. The quantitative capabilities and low detection limits demonstrated by paper spray mass spectrometry offer distinct benefits over existing on-site drug checking methods and harm reduction services.en_US
dc.description.sponsorshipThis work was supported by the Natural Science and Engineering Research Council of Canada Discovery Grant Program funding (RGPIN-2016-05380), Vancouver Island University and the Health Canada Drug Checking Technology Challenge.en_US
dc.format.extent9 pg.en
dc.format.mediumtexten
dc.format.mimetypeapplication/pdfen
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rightsAttribution NonCommercial No Derivatives 4.0 Internationalen
dc.subject.lcshFentanylen
dc.subject.lcshHarm reductionen
dc.subject.lcshOpioids--Samplingen
dc.subject.lcshMass spectrometryen
dc.subject.lcshBenzodiazepinesen
dc.subject.otherEtizolamen
dc.titleA new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometryen_US
dc.typeArticleen_US
dc.description.noteThis article was originally published as: Borden, S.A., Saatchi, A., Vandergrift, G.W., Palaty, J., Lysyshyn, M., & Gill, C.G. (2021). A new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry. Drug and Alcohol Review, 1-8. https://doi.org/10.1111/dar.13370 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en
dc.description.fulltexthttps://viurrspace.ca/bitstream/handle/10613/24515/Gill2021.pdf?sequence=3en
dc.identifier.doi10.1111/dar.13370


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