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    [Post-print] A new mass spectrometry based approach for organic synthesis monitoring

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    Post-print (903.2Kb)
    Date
    2019-08-12
    Author
    Termopoli, Veronica
    Torrisi, Elena
    Famiglini, Giorgio
    Palma, Pierangela
    Zappia, Giovanni
    Cappiello, Achille
    Vandergrift, Gregory W.
    Zvekic, Misha
    Krogh, Erik T.
    Gill, Chris G.
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    Abstract
    Current mass spectrometry-based methodologies for synthetic organic reaction monitoring largely use electrospray ionization (ESI), or other related atmospheric pressure ionization-based approaches. Monitoring of complex, heterogeneous systems may be problematic because of sampling hardware limitations, and many relevant analytes (neutrals) exhibit poor ESI performance. An alternative monitoring strategy addressing this significant impasse is condensed phase membrane introduction mass spectrometry using liquid electron ionization (CP-MIMS-LEI). In CP-MIMS, a semi-permeable silicone membrane selects hydrophobic neutral analytes, rejecting particulates and charged chemical components. Analytes partition through the membrane, and are then transported to the LEI interface for sequential nebulization, vaporization, and ionization. CP-MIMS and LEI are both ideal for continuous monitoring applications of hydrophobic neutral molecules. We demonstrate quantitative reaction monitoring of harsh, complex reaction mixtures (alkaline, acidic, heterogeneous) in protic and aprotic organic solvents. Also presented are solvent-membrane compatibility investigations, and in situ, quantitative monitoring of catalytic oxidation and alkylation reactions.
    Description
    Post-print
    URI
    https://viurrspace.ca/handle/10613/23371
    http://dx.doi.org/10.25316/IR-15270
    Identifier (Other)
    DOI: 10.1021/acs.analchem.9b02681
    DOI: 10.25316/IR-15270
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    • Gill, Chris
    • Krogh, Erik
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