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dc.contributor.authorBorden, Scott A.
dc.contributor.authorSaatchi, Armin
dc.contributor.authorKrogh, Erik T.
dc.contributor.authorGill, Chris G.
dc.date.accessioned2020-09-18T19:54:20Z
dc.date.available2020-09-18T19:54:20Z
dc.date.issued2020-08-22
dc.identifier.citationBorden, S.A., Saatchi, A., Krogh, E.T., & Gill, C.G. (2020). Rapid and quantitative determination of fentanyls and pharmaceuticals from powdered drug samples by paper spray mass spectrometry. Analytical Science Advances, 2(1), 97-108. https://doi.org/10.1002/ansa.202000083en_US
dc.identifier.issn2628-5452
dc.identifier.otherDOI: 10.1002/ansa.202000083
dc.identifier.otherDOI: 10.25316/IR-15259
dc.identifier.urihttps://viurrspace.ca/handle/10613/23357
dc.identifier.urihttp://dx.doi.org/10.25316/IR-15259
dc.description.abstractPaper spray mass spectrometry is presented as a direct, quantitative tool for the measurement of pharmaceutical drugs and a variety of fentanyl analogs in solid samples and powder slurries with the ultimate goal of providing meaningful harm-reduction drug checking. Method development and validation was carried out for fentanyl analog slurries as a proxy for street drug samples. Lower limits of quantitation were determined to be 3.6-7.4 ng/g for fentanyl analogs in the pharmaceutical slurry matrix. Using 1mg of solid sample, the method can quantify picogram quantities of these drugs, well below required thresholds for even the most potent fentanyl analogs. Quality control samples were prepared and used to assess method validity according to the Scientific Working Group for Forensic Toxicology (SWGTOX) guidelines. Performance metrics for both precision and accuracy were found to be within SWGTOX-recommended guidelines. Additionally, pharmaceutical tablets were used to demonstrate the applicability of the developed paper spray methodology for the direct qualitative and quantitative analysis of active ingredients in pharmaceutical powders deposited directly onto the paper spray substrate. A proposed workflow for rapid solid drug sample measurements is presented with potential applications for point-of-use street drug measurements and other solid sample matrices.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada, Grant/Award Number: RGPIN-2016-05380en_US
dc.format.extent12 pg.en
dc.format.mediumtexten
dc.format.mimetypeapplication/pdfen
dc.language.isoenen_US
dc.publisherWiley-VCHen_US
dc.rightsAttribution NonCommercial No Derivatives 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subject.lcshFentanylen
dc.subject.lcshOpioids--Samplingen
dc.subject.lcshHarm reductionen
dc.subject.lcshMass spectrometryen
dc.titleRapid and quantitative determination of fentanyls and pharmaceuticals from powdered drug samples by paper spray mass spectrometryen_US
dc.typeArticleen_US
dc.description.noteThis article was originally published as: Borden, S.A., Saatchi, A., Krogh, E.T., & Gill, C.G. (2020). Rapid and quantitative determination of fentanyls and pharmaceuticals from powdered drug samples by paper spray mass spectrometry. Analytical Science Advances, 2(1), 97-108. https://doi.org/10.1002/ansa.202000083 Analytical Science Advances, an open-access journal published by Wiley-VCH, is available online at: https://onlinelibrary.wiley.com/journal/26285452. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en
dc.description.fulltexthttps://viurrspace.ca/bitstream/handle/10613/23357/KroghGill2020ANSA.pdf?sequence=3en
dc.identifier.doi10.1002/ansa.202000083
dc.identifier.doi10.25316/IR-15259


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Attribution NonCommercial No Derivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution NonCommercial No Derivatives 4.0 International