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dc.contributor.authorKennedy, Joseph H.
dc.contributor.authorPalaty, Jan
dc.contributor.authorGill, Chris G.
dc.contributor.authorWiseman, Justin M.
dc.date.accessioned2019-06-17T17:36:32Z
dc.date.available2019-06-17T17:36:32Z
dc.date.issued2018-08-15
dc.identifier.citationKennedy, J.H., Palaty, J., Gill, C.G., & Wiseman, J.M. (2018). Rapid analysis of fentanyls and other novel psychoactive substances (NPS) in substance use disorder patient urine using paper spray mass spectrometry. Rapid Communications in Mass Spectrometry, 32(15), 1280-1286. DOI: 10.1002/rcm.8164en
dc.identifier.issn0951-4198
dc.identifier.otherDOI: 10.1002/rcm.8164
dc.identifier.otherDOI: 10.25316/IR-7093
dc.identifier.urihttp://hdl.handle.net/10613/12782
dc.identifier.urihttp://dx.doi.org/10.25316/IR-7093
dc.descriptionPost-printen
dc.description.abstractRATIONALE: Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies to identify and quantitate NPS. METHODS: Paper spray tandem mass spectrometry and high-resolution mass spectrometry were used to identify and measure fentanyl analogs as well as common drugs of abuse in urine samples from substance use disorder clinics. Ten-microliter urine samples were deposited directly on paper spray cartridges previously loaded with internal standards, dried, and analyzed with no other sample treatment. Quantitative results were obtained using tandem mass spectrometry (MS/MS). Individual drugs were identified using high resolution accurate mass spectrometry (HRAM), and confirmed by data dependent MS/MS. RESULTS: Calibration curves in urine were linear over a range of 0.5 - 50 ng/mL with R2 of 0.99 or better for eight representative fentanyl analogs. Cartridges preloaded with internal standards demonstrated satisfactory quantitative results compared with LC/MS. Direct identification and confirmation of fentanyl analogs and other common drugs of abuse in urine using high resolution accurate mass and MS/MS fragmentation were demonstrated at low picogram levels. CONCLUSIONS: Paper spray mass spectrometry can reliably identify and quantitate fentanyl analogs and other drugs of abuse in urine. Using paper spray cartridges as collection devices reduces exposure and transportation risks associated with biological fluids. Cartridges pre-loaded with labeled internal standards can be effective for targeted screening of fentanyl analogs and other drugs of abuse.en
dc.description.sponsorshipChris Gill would like to acknowledge the Natural Sciences and Engineering Research Council of Canada (NSERC) for funding under the Discovery Grants program (RGPIN-2016-05380), Vancouver Island University for their ongoing support of my research program, and an anonymous Vancouver Island University Foundation donor who funded the necessary travel to facilitate this timely collaboration.en
dc.format.extent18 pg.en
dc.format.mediumtexten
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.subject.lcshFentanylen
dc.subject.lcshOpioids--Samplingen
dc.subject.lcshHarm reductionen
dc.subject.lcshMass spectrometryen
dc.subject.lcshOpioids--Measurementen
dc.title[Post-print] Rapid analysis of fentanyls and other novel psychoactive substances (NPS) in substance use disorder patient urine using paper spray mass spectrometryen
dc.typeArticleen
dc.description.versionPost-print versionen
dc.description.noteThis is the peer reviewed version of the following article: Kennedy, J.H., Palaty, J., Gill, C.G., & Wiseman, J.M. (2018). Rapid analysis of fentanyls and other novel psychoactive substances (NPS) in substance use disorder patient urine using paper spray mass spectrometry. Rapid Communications in Mass Spectrometry, 32(15), 1280-1286. DOI: 10.1002/rcm.8164, which has been published in final form at http://dx.doi.org/10.1002/rcm.8164. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.description.fulltexthttps://viurrspace.ca/bitstream/handle/10613/12782/Gill.RCM2018.pdf?sequence=4en
dc.identifier.doi10.1002/rcm.8164
dc.identifier.doi10.25316/IR-7093


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